A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.
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منابع مشابه
A Combination of HLA - DQ , # Asp 57 - Negative and HLA DQa Arg 52 Confers Susceptibility to Insulin - dependent Diabetes Mellitus
Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ/i chain is positively correlated to IDDM. However, Asp57-negative haplotypes do not always confer susceptibility and conversely, some Asp57-positive haplotypes seem to be disease a...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1990
ISSN: 0021-9738
DOI: 10.1172/jci114569